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Preprints
1. T. Sych, F. Weber, J. Schlegel, R. B. Bostancioglu, H. M.G. Barriga, K. Ezzat, H. Stangl, B. Plochberger, S. El Andaloussi, M. M. Stevens, J. Laurencikiene, E. Sezgin, Single particle profiler for measuring properties of nano-sized bioparticles BioRxiv , 499323 (2022)
2. D. Cikes, K. Elsayad, E. Sezgin, E. Koitai, T. Ferenc, M. Orthofer, R. Yarwood, L. X. Heinz, V. Sedlyarov, N. D. Miranda, A. Taylor, S. Grapentine, F. al-Murshedi, A. Abott, A. Weidinger, C. Kutchukian, C. Sanchez, S. J.F. Cronin, M. Novatchkova, A. Kavirayani, T. Schuetz, Bernhard Haubner, L. Haas, A. Hagelkruys, S. Jackowski, A. Kozlov, V. Jacquemond, C. Knauf, G. Superti-Furga, E. Rullman, T. Gustafsson, J. McDermot, M. Lowe, Z. Radak, J. S. Chamberlain, M. Bakovic, S. Banka, J.M. Penninger, PCYT2 controls muscle health and muscle aging, BioRxiv , 482658 (2022)
3. H. Leng, H. Zhang, L. Li, S. Zhang, Y. Wang, A. Ersek, E. Morris, E. Sezgin, Y-H. Lee, Y Li, J Mi, Q Zhong, C. Edwards, A. K. Simon, N. J. Horwood. The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease BioRxiv , 429906 (2021)
2022
81. C. O. Gurdap, L. Wedemann, T. Sych, E Sezgin, The influence of the extracellular domains on the dynamic behavior of membrane proteins Biophysical Journal , (2022)
80. F. Ragaller, L. Andronico, J. Sykora, W. Kulig, T. Rog, Y.B. Urem, Abhinav, D.I. Danylchuk, M. Hof, A. Klymchenko, M. Amaro, I. Vattulainen, E. Sezgin, Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties Open Biology , 12: 220175 (2022)
79. P. F. Céspedes, A. K. Jainarayanan, L. Fernández-Messina, S. Valvo, D. G. Saliba, E. Kurz, A. Kvalvaag, L. Chen, C. Ganskow, H. Colin-York, M. Fritzsche, Y. Peng, T. Dong, E. Jonhson, J. A. Siller-Farfán, O. Dushek, E. Sezgin, B. Peacock, A. Law, D. Aubert, S. Engledow, M. Attar, S. Haster, R. Fisher, F. Sánchez-Madrid, M.L. Dustin T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles. Nature Communications 13, 3460 (2022)
78. M. Brameshuber, E. Klotzsch, A. Ponjavic, E. Sezgin, Understanding immune signaling using advanced imaging techniques. Biochemical Society Transactions, BST20210479, (2022)
77. L. Delemotte, S.L. Garcia, A. Rodríguez-Gijón, E Sezgin, A. Vihervaara, Uniting diversity to create a more inclusive academic environment Journal of Cell Science, 135(7):jcs259977, (2022)
76. S. Galiani, K. Reglinski, P. Carravilla, A. Barbotin, I. Urbančič, J. Ott, J. Sehr, E. Sezgin, F. Schneider, D Waithe, P Hublitz, W Schliebs, R Erdmann, C Eggeling Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 Biophysical Reports, (2022)
75. L. Hanke, H. Das, D.J. Sheward, L. P. Vidakovics, E. Urgard, A. Moliner-Morro, C Kim, V Karl, A Pankow, N L Smith, B Porebski, O Fernandez-Capetillo, E. Sezgin, G. K. Pedersen, J. M Coquet, B. M. Hällberg, B. Murrell, G. M. McInerney, A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo Nature Communications, (2022)
74. T. Sych, K. Levental, E. Sezgin, Lipid–Protein Interactions in Plasma Membrane Organization and Function Annual Reviews of Biophysics, 51 (2022)
73. E. Sezgin, Giant plasma membrane vesicles to study plasma membrane structure and dynamics BBA Biomembranes, (2022)
2021
72. I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D Charles, A. Soragia Gkazi, E. Adamopoulou, W. Qasim, E.G. Davies, C. Hanson, A. T. Pagnamenta, C. Camps, H. M. Dreau, A. White, K. James, R. Fischer, .O. Gileadi, J. C. Taylor, T. Fulga, B.C. Lagerholm, G. Anderson, E. Sezgin, G. A. Hollander A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency Science Advances, (accepted)
71. M. Matias, C. Yong, A. Foroushani, E. Sezgin, K. Levental, A. Talebi, C. Mongellaz, J. Dehair, M. Wong, S. Kinet, V.S. Zimmermann, I. Levental, L. Yvan-Charvet, J. Swinnen, S. Muljo, S. Tardito, V. Dardalhon, N. Taylor, Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis Cell Reports, (2021)
70. P. Carravilla*, A. Dasgupta, G. Zhurgenbayeva, D. I. Danylchuk, A. S. Klymchenko, E. Sezgin*, C. Eggeling. STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes Biophysical Reports, (2021)
69. I. Urbancic*, L. Schiffelers, E. Jenkins, W. Gong, A. M. Santos, F. Schneider, C. O'Brian Ball, M. T. Vuong, N. Ashman, E.Sezgin*, C. Eggeling* . Aggregation and partial immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells FEBS Letters , (2021)
68. B.E. Oftedal, S. Maio, A. Handel, M.P.J. White, D. Howie, S. Davis, N. Prevot, I.A. Rota, M.E. Deadman, B. M Kessler, R. Fischer, N.S. Trede, E. Sezgin, R.M. Maizels, G.A. Holländer, The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function Communications Biology , (2021)
67. T.Sych, C. O. Gurdap, L. Wedemann, E. Sezgin, How Does Liquid-Liquid Phase Separation in Model Membranes Reflect Cell Membrane Heterogeneity? Membranes, (2021)
66. J. H. Felce, L. Parolini, E. Sezgin, P. F. Céspedes, K. Korobchevskaya, M. Jones, Y. Peng, T. Dong, M. Fritzsche, D. Aarts, J. Frater, M. L. Dustin, Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behaviour within the T cell immunological synapse Frontiers in Cell and Developmental Biology, (2021)
65. O. Ozalp, O. Cark, Y. Azbazdar, B. Haykir, G. Cucun, I. Kucukaylak, G. Alkan-Yesilyurt, E Sezgin, G. Ozhan, Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis Biomolecules, (2021)
2020
64. F Schneider, C Eggeling, E Sezgin, Influence of nanobody binding on fluorescence emission, mobility and organization of GFP-tagged proteins iScience , (2020)
63. B. Plochberger, T Sych, F Weber, J Novacek, M Axmann, H Stangl, E Sezgin, Lipoprotein particles interact with membranes and transfer their cargo without receptors Biochemistry, (2020)
62. D.I. Danylchuk*, E. Sezgin*, P. Chabert, and A.S. Klymchenko, Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes, Analytical Chemistry, (2020) (* Co-first)
61. J.J. Lühr, N. Alex, L. Amon, M. Kräter, M. Kubánková, E. Sezgin, C. H. Lehmann, L. Heger, G. Heidkamp, A-S Smith, V Zaburdaev, R. A. Böckmann, I. Levental, M. L. Dustin, C. Eggeling, J. Guck, and D. Dudziak, Maturation of monocyte-derived DCs leads to increased cellular stiffness, higher membrane fluidity, and changed lipid composition, Frontiers in Immunology, (2020)
60. K. Reglinski, L.L. Steinfort, E. Sezgin, C. Klose, HW Platta, W. Girzalsky, C. Eggeling, R. Erdmann, Fluidiy and lipid composition of membranes of peroxisomes, mitochondria and ER from oleic-acid induced Saccharomyces cerevisiae, Frontiers in Cell and Developmental Biology, (2020)
59. P. Cespedes, D. Beckers, M. Dustin, E. Sezgin, Model membrane systems to reconstitute immune cell signaling, FEBS Journal, (2020)
58. A. Frawley, V. Wyciks, Y. Xiong, S. Galiani, E. Sezgin, I. Urbancic, A.V. Jentzsch, K. Leslie, C. Eggeling, H. Anderson, Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad , Chemical Science, (2020)
57. C. Sieben, E. Sezgin, C. Eggeling, S. Manley Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation Plos Pathogens, (2020)
56. Barbotin A, Urbancic I, Galiani S, Eggeling C, Booth M, Sezgin E, z-STED imaging and spectroscopy to investigate nanoscale membrane structure and dynamics, Biophysical Journal, (2020)
55. Sezgin E, Carugo D, Levental I, Stride E, Eggeling C, Creating supported plasma membrane bilayers using acoustic pressure, Membranes, 10(2), 30, (2020)
54. Lorent JH, Levental K, Ganesan L, Rivera-Longsworth G, Sezgin E, Doktorova M, Lyman E, Levental I, Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape, Nature Chemical Biology , (2020)
53. Beckers D, Urbancic D, Sezgin E, Impact of nanoscale hindrances on the relationship between lipid packing and diffusion in model membranes, Journal of Physical Chemistry B (2020)
52. Ballweg S, Sezgin E, Wunnicke D, Hänelt I, and Ernst R, Regulation of lipid saturation without sensing membrane fluidity Nature Communications, 756 (2020).
See press release here
51. Schneider F, Hernandez-Varas P, Lagerholm CB, Shrestha D, Sezgin E, Roberti MJ, Ossato G, Hecht F, Eggeling C, Urbancic I, High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy. Journal of Physics D, 53, 164003 (2020)
2019
50. Azbazdar Y, Ozalp O, Sezgin E, Veerapathiran S, Duncan A, Sansom M, Eggeling C, Wohland T, Karaca E, Ozhan G. More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Frontiers in Cell and Dev Biology, (2019)
49. Steinkuhler J, Sezgin E, Urbancic I, Eggeling C, Dimova R. Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density. Communications Biology, (2019)
48. Pinkwart K, Schneider F, Lukoseviciute M, Sauka-Spengler T, Lyman E, Eggeling C, Sezgin E. Nanoscale dynamics of cholesterol in the cell membrane. Journal of Biological Chemistry, (2019)
47. Axmann M, Sezgin E, Karner A, Novacek J, Brodesser MD, Röhrl C, Preiner J, Stangl H, Plochberger B. Receptor-Independent Transfer of Low Density Lipoprotein Cargo to Biomembranes. Nano Letters, 19(4), 2562-2567, (2019)
46. Sezgin E, Schneider F, Galiani S, Urbančič I, Waithe D, Lagerholm BC, Eggeling C. Measuring nanoscale diffusion dynamics in cellular membranes with super-resolution STED-FCS. Nature Protocols, 14(4), 1054-1083, (2019)
2018
45. Felce JH*, Sezgin E*, Wane M, Brouwer H, Dustin ML, Eggeling C, Davis SJ. CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity. Science Signalling, 11(561), (2018)
44. Jenkins E, Santos AM, O'Brien-Ball C, Felce JH, Wilcock MJ, Hatherley D, Dustin ML, Davis SJ, Eggeling C, Sezgin E. Reconstitution of immune cell interactions in free-standing membranes. Journal of Cell Science, 132(4), (2018)
43. Mobarak E, Javanainen M, Kulig W, Honigmann A, Sezgin E, Aho N, Eggeling C, Rog T, Vattulainen I. How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative. BBA Biomembranes, 1860(11), 2436-2445, (2018)
42. Schneider F, Waithe D, Lagerholm BC, Shrestha D, Sezgin E, Eggeling C, Fritzsche M. Statistical Analysis of Scanning Fluorescence Correlation Spectroscopy Data Differentiates Free from Hindered Diffusion. ACS Nano, 12(8), 8540-8546, (2018)
41. Schneider F, Waithe D, Galiani S, Bernardino de la Serna J, Sezgin E*, Eggeling C*. Nanoscale Spatiotemporal Diffusion Modes Measured by Simultaneous Confocal and Stimulated Emission Depletion Nanoscopy Imaging. Nano Letters, (2018) (*co-correspondence)
40. Reina F, Galiani S, Shrestha D, Sezgin E, de Wit G, Cole D, Christoffer Lagerholm B, Kukura P, Eggeling C. Complementary studies of lipid membrane dynamics using iSCAT and super-resolved fluorescence correlation spectroscopy. Journal of Physics D, (2018)
39. Xiong Y, Jentzsch AV, Osterrieth JWM, Sezgin E, Sazanovich IV, Reglinski K, Galiani S, Parker AW, Eggeling C, Anderson HL. Spironaphthoxazine switchable dyes for biological imaging Chemical Science, (2018)
38. Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J. Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. European Journal of Immunology, (2018)
2017
37. Plochberger B, Röhrl C, Preiner J, Rankl C, Brameshuber M, Madl J, Bittman R, Ros R, Sezgin E, Eggeling C, Hinterdorfer P, Stangl H, Schütz GJ. HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study. Scientific Reports, 7(1), 15886, (2017)
36. Sezgin E, Schneider F, Zilles V, Urbančič I, Garcia E, Waithe D, Klymchenko AS, Eggeling C. Polarity-Sensitive Probes for Superresolution Stimulated Emission Depletion Microscopy. Biophysical Journal, (2017)
35. Diepold A, Sezgin E, Huseyin M, Mortimer T, Eggeling C, Armitage JP. A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome. Nature Communications, 8, 15940, (2017)
34. Sezgin E*, Azbazdar Y, Ng XW, Teh C, Simons K, Weidinger G, Wohland T, Eggeling C, Ozhan G*. Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments. FEBS Journal, (2017) (*co-correspondence)
33. Sezgin E. Super-resolution optical microscopy for studying membrane structure and dynamics. Journal of Physics Condensed Matter, (2017)
32. Aron M, Browning R, Carugo D, Sezgin E, Bernardino de la Serna J, Eggeling C, Stride E. Spectral imaging toolbox: segmentation, hyperstack reconstruction, and batch processing of spectral images for the determination of cell and model membrane lipid order. BMC Bioinformatics, 18 (1), 254 (2017)
31. Rissanen S, Grzybek M, Orlowski A, Rog T, Cramariuc O, Levental I, Eggeling C, Sezgin E*, Vattulainen I*. Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin Frontiers in Physiology, (2017) (*co-correspondence)
30. Schneider F, Waithe D, Clausen MP, Galiani S, Koller T, Ozhan G, Eggeling C*, Sezgin E*. Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS. Molecular Biology of the Cell, (2017) (*co-correspondence)
29. Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane organization: composition, regulation and roles of lipid rafts Nature Reviews Molecular Cell Biology, (2017)
28. Pereno V, Carugo D, Bau L, Sezgin E, de la Serna JB, Eggeling E, Stride E. Electroformation of giant unilamellar vesicles on stainless steel electrodes, ACS Omega, 2(3), 994–1002 (2017)
27. Koller T, Blok S, Santos AM, Oszmiana A, Davis DM, Sezgin E*, Eggeling C. Rituximab capping triggers intracellular reorganization of B cells. Matters, (2017) (*correspondence)
26. Amaro M, Reina F, Hof M, Eggeling C, Sezgin E*. Laurdan and Di-4-ANEPPDHQ probe different properties of the membrane. Journal of Physics D: Applied Physics, 50(13), 134004-134013, (2017)
25. Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras G, Betzig B, Eggeling C. Self-organizing actin patterns shape membrane architecture but not cell mechanics. Nature Communications, 8, 14347 (2017)
24. Carugo D, Aron M, Sezgin E, Bernardino de la Serna J, Kuimova MK, Eggeling C, Stride E. Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles. Biomaterials, 113, 105-117 (2016)
2016
23. Xiong Y, Rivera-Fuentes P, Sezgin E, Vargas Jentzsch A, Eggeling C, Anderson HL. Photoswitchable Spiropyran Dyads for Biological Imaging. Organic Letters, 18(15), 3666-3669 (2016)
22. Steshenko O, Andrade DM, Honigmann A, Mueller V, Schneider F, Sezgin E, Hell SW, Simons M, Eggeling C. Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy. Biophysical Journal, 110(11), 2441-2450 (2016)
21. Hölttä-Vuori M, Sezgin E, Eggeling C, Ikonen E. Use of BODIPY-cholesterol (TF-Chol) for visualizing lysosomal cholesterol accumulation. Traffic, (2016)
20. Sezgin E*, Can FB, Schneider F, Clausen MP, Galiani S, Stanly TA, Waithe D, Colaco A, Honigmann A, Wuestner D, Platt F, Eggeling C*. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters. Journal of Lipid Research, (2016). (*co-correspondence)
2015
19. Waithe D, Clausen MP, Sezgin E, Eggeling C. FoCuS-point: Software for STED Fluorescence Correlation and Time-Gated Single Photon Counting. Bioinformatics, (2015).
18. Vicidomini G, Ta H, Honigmann A, Mueller V, Clausen MP, Waithe D, Galiani S, Sezgin E, Diaspro A, Hell SW, Eggeling C. STED-FLCS: An Advanced Tool to Reveal Spatiotemporal Heterogeneity of Molecular Membrane Dynamics. Nano Letters, 15(9), 5912-5918, (2015).
17. Clausen MP, Sezgin E, de la Serna JB, Waithe D, Christoffer Lagerholm B, Eggeling C. A straightforward approach for gated STED-FCS to investigate lipid membrane dynamics. Methods, 88, 67-75, (2015).
16. Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun U, Solimena M, Simons K, Levental I*, Schwille P*. Adaptive lipid packing and bioactivity in the membrane domains. PLOS ONE, 10(4); e0123930 (2015).
15. Sezgin E, Davis SJ, Eggeling C. Membrane nanoclusters—tails of the unexpected. Cell, 161, 433-434 (2015).
14. Sezgin E*, Waithe D, Bernardino de la Serna J, Eggeling C*. Spectral Imaging to measure heterogeneity in membrane lipid packing. Chemphyschem, 16(7), 1387-1394. (2015). (*co-correspondence)
13. Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW. Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains. BBA Molecular Cell Research, 1853 (4), 802-809, (2015).
2014
12. Honigmann A, Mueller V, Ta H, Schoenle A, Sezgin E, Hell SW, Eggeling C. (2014) Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells. Nature Communications, 5, 5412, (2014).
11. Sezgin E*, Sadowski T, Simons K*. Measuring Lipid Packing of Model and Cellular Membranes with Environment Sensitive Probes. Langmuir, 30, 8160-8166, (2014). (*co-correspondence)
2013
10. Zhou Y, Maxwell KN, Sezgin E, Lu M, Liang H, Hancock JF, Dial EJ, Lichtenberger LM, Levental I. Bile acids modulate signaling by functional perturbation of plasma membrane domains. Journal of Biological Chemistry, 288, 35660-35670, (2013).
9. Sezgin E, Chwastek G, Aydogan G, Levental I, Simons K, Schwille P. Photoconversion of Bodipy-Labeled Lipid Analogues. Chembiochem, 14, 695-698, (2013).
8. Ozhan G, Sezgin E, Wehner D, Pfister A, Kuhl S, Kagermeier-Schenk B, Kuhl M, Schwille P, Weidinger G. Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Developmental Cell, 26, 331-345, (2013).
2012
7. Sezgin E, Kaiser H-J, Baumgart T, Schwille P, Simons K, Levental I. Elucidating membrane structure and protein behavior using giant plasma membrane vesicles. Nature Protocols, 7, 1042-1051, (2012).
6. Sezgin E, Levental I, Grzybek M, Schwarzmann G, Mueller V, Honigmann A, Belov VN, Eggeling C, Coskun U, Simons K, Schwille P. Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. BBA-Biomembranes, 1818, 1777-1784, (2012).
5. Dubavik A*, Sezgin E*, Lesnyak V, Gaponik N, Schwille P, Eychmueller A. Penetration of Amphiphilic Quantum Dots through Model and Cellular Plasma Membranes. ACS Nano, 6, 2150-2156, (2012). (*co-first author)
4. Saenz JP, Sezgin E, Schwille P, Simons K. Functional convergence of hopanoids and sterols in membrane ordering. PNAS, 109, 14236-14240, (2012).
3. Sezgin E and Schwille P. Model membrane platforms to study protein-membrane interactions. Molecular Membrane Biology, 29, 144-154,(2012).
2011
2. Sezgin E and Schwille P. Fluorescence Techniques to Study Lipid Dynamics. Cold Spring Harbor Perspectives in Biology, 3, (2011).
2009
1. Karatas OF, Sezgin E, Aydin O, Culha M. Interaction of gold nanoparticles with mitochondria. Colloids and Surfaces B-Biointerfaces, 71, 315-318, (2009).
1. T. Sych, F. Weber, J. Schlegel, R. B. Bostancioglu, H. M.G. Barriga, K. Ezzat, H. Stangl, B. Plochberger, S. El Andaloussi, M. M. Stevens, J. Laurencikiene, E. Sezgin, Single particle profiler for measuring properties of nano-sized bioparticles BioRxiv , 499323 (2022)
2. D. Cikes, K. Elsayad, E. Sezgin, E. Koitai, T. Ferenc, M. Orthofer, R. Yarwood, L. X. Heinz, V. Sedlyarov, N. D. Miranda, A. Taylor, S. Grapentine, F. al-Murshedi, A. Abott, A. Weidinger, C. Kutchukian, C. Sanchez, S. J.F. Cronin, M. Novatchkova, A. Kavirayani, T. Schuetz, Bernhard Haubner, L. Haas, A. Hagelkruys, S. Jackowski, A. Kozlov, V. Jacquemond, C. Knauf, G. Superti-Furga, E. Rullman, T. Gustafsson, J. McDermot, M. Lowe, Z. Radak, J. S. Chamberlain, M. Bakovic, S. Banka, J.M. Penninger, PCYT2 controls muscle health and muscle aging, BioRxiv , 482658 (2022)
3. H. Leng, H. Zhang, L. Li, S. Zhang, Y. Wang, A. Ersek, E. Morris, E. Sezgin, Y-H. Lee, Y Li, J Mi, Q Zhong, C. Edwards, A. K. Simon, N. J. Horwood. The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease BioRxiv , 429906 (2021)
2022
81. C. O. Gurdap, L. Wedemann, T. Sych, E Sezgin, The influence of the extracellular domains on the dynamic behavior of membrane proteins Biophysical Journal , (2022)
80. F. Ragaller, L. Andronico, J. Sykora, W. Kulig, T. Rog, Y.B. Urem, Abhinav, D.I. Danylchuk, M. Hof, A. Klymchenko, M. Amaro, I. Vattulainen, E. Sezgin, Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties Open Biology , 12: 220175 (2022)
79. P. F. Céspedes, A. K. Jainarayanan, L. Fernández-Messina, S. Valvo, D. G. Saliba, E. Kurz, A. Kvalvaag, L. Chen, C. Ganskow, H. Colin-York, M. Fritzsche, Y. Peng, T. Dong, E. Jonhson, J. A. Siller-Farfán, O. Dushek, E. Sezgin, B. Peacock, A. Law, D. Aubert, S. Engledow, M. Attar, S. Haster, R. Fisher, F. Sánchez-Madrid, M.L. Dustin T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles. Nature Communications 13, 3460 (2022)
78. M. Brameshuber, E. Klotzsch, A. Ponjavic, E. Sezgin, Understanding immune signaling using advanced imaging techniques. Biochemical Society Transactions, BST20210479, (2022)
77. L. Delemotte, S.L. Garcia, A. Rodríguez-Gijón, E Sezgin, A. Vihervaara, Uniting diversity to create a more inclusive academic environment Journal of Cell Science, 135(7):jcs259977, (2022)
76. S. Galiani, K. Reglinski, P. Carravilla, A. Barbotin, I. Urbančič, J. Ott, J. Sehr, E. Sezgin, F. Schneider, D Waithe, P Hublitz, W Schliebs, R Erdmann, C Eggeling Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 Biophysical Reports, (2022)
75. L. Hanke, H. Das, D.J. Sheward, L. P. Vidakovics, E. Urgard, A. Moliner-Morro, C Kim, V Karl, A Pankow, N L Smith, B Porebski, O Fernandez-Capetillo, E. Sezgin, G. K. Pedersen, J. M Coquet, B. M. Hällberg, B. Murrell, G. M. McInerney, A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo Nature Communications, (2022)
74. T. Sych, K. Levental, E. Sezgin, Lipid–Protein Interactions in Plasma Membrane Organization and Function Annual Reviews of Biophysics, 51 (2022)
73. E. Sezgin, Giant plasma membrane vesicles to study plasma membrane structure and dynamics BBA Biomembranes, (2022)
2021
72. I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D Charles, A. Soragia Gkazi, E. Adamopoulou, W. Qasim, E.G. Davies, C. Hanson, A. T. Pagnamenta, C. Camps, H. M. Dreau, A. White, K. James, R. Fischer, .O. Gileadi, J. C. Taylor, T. Fulga, B.C. Lagerholm, G. Anderson, E. Sezgin, G. A. Hollander A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency Science Advances, (accepted)
71. M. Matias, C. Yong, A. Foroushani, E. Sezgin, K. Levental, A. Talebi, C. Mongellaz, J. Dehair, M. Wong, S. Kinet, V.S. Zimmermann, I. Levental, L. Yvan-Charvet, J. Swinnen, S. Muljo, S. Tardito, V. Dardalhon, N. Taylor, Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis Cell Reports, (2021)
70. P. Carravilla*, A. Dasgupta, G. Zhurgenbayeva, D. I. Danylchuk, A. S. Klymchenko, E. Sezgin*, C. Eggeling. STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes Biophysical Reports, (2021)
69. I. Urbancic*, L. Schiffelers, E. Jenkins, W. Gong, A. M. Santos, F. Schneider, C. O'Brian Ball, M. T. Vuong, N. Ashman, E.Sezgin*, C. Eggeling* . Aggregation and partial immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells FEBS Letters , (2021)
68. B.E. Oftedal, S. Maio, A. Handel, M.P.J. White, D. Howie, S. Davis, N. Prevot, I.A. Rota, M.E. Deadman, B. M Kessler, R. Fischer, N.S. Trede, E. Sezgin, R.M. Maizels, G.A. Holländer, The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function Communications Biology , (2021)
67. T.Sych, C. O. Gurdap, L. Wedemann, E. Sezgin, How Does Liquid-Liquid Phase Separation in Model Membranes Reflect Cell Membrane Heterogeneity? Membranes, (2021)
66. J. H. Felce, L. Parolini, E. Sezgin, P. F. Céspedes, K. Korobchevskaya, M. Jones, Y. Peng, T. Dong, M. Fritzsche, D. Aarts, J. Frater, M. L. Dustin, Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behaviour within the T cell immunological synapse Frontiers in Cell and Developmental Biology, (2021)
65. O. Ozalp, O. Cark, Y. Azbazdar, B. Haykir, G. Cucun, I. Kucukaylak, G. Alkan-Yesilyurt, E Sezgin, G. Ozhan, Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis Biomolecules, (2021)
2020
64. F Schneider, C Eggeling, E Sezgin, Influence of nanobody binding on fluorescence emission, mobility and organization of GFP-tagged proteins iScience , (2020)
63. B. Plochberger, T Sych, F Weber, J Novacek, M Axmann, H Stangl, E Sezgin, Lipoprotein particles interact with membranes and transfer their cargo without receptors Biochemistry, (2020)
62. D.I. Danylchuk*, E. Sezgin*, P. Chabert, and A.S. Klymchenko, Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes, Analytical Chemistry, (2020) (* Co-first)
61. J.J. Lühr, N. Alex, L. Amon, M. Kräter, M. Kubánková, E. Sezgin, C. H. Lehmann, L. Heger, G. Heidkamp, A-S Smith, V Zaburdaev, R. A. Böckmann, I. Levental, M. L. Dustin, C. Eggeling, J. Guck, and D. Dudziak, Maturation of monocyte-derived DCs leads to increased cellular stiffness, higher membrane fluidity, and changed lipid composition, Frontiers in Immunology, (2020)
60. K. Reglinski, L.L. Steinfort, E. Sezgin, C. Klose, HW Platta, W. Girzalsky, C. Eggeling, R. Erdmann, Fluidiy and lipid composition of membranes of peroxisomes, mitochondria and ER from oleic-acid induced Saccharomyces cerevisiae, Frontiers in Cell and Developmental Biology, (2020)
59. P. Cespedes, D. Beckers, M. Dustin, E. Sezgin, Model membrane systems to reconstitute immune cell signaling, FEBS Journal, (2020)
58. A. Frawley, V. Wyciks, Y. Xiong, S. Galiani, E. Sezgin, I. Urbancic, A.V. Jentzsch, K. Leslie, C. Eggeling, H. Anderson, Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad , Chemical Science, (2020)
57. C. Sieben, E. Sezgin, C. Eggeling, S. Manley Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation Plos Pathogens, (2020)
56. Barbotin A, Urbancic I, Galiani S, Eggeling C, Booth M, Sezgin E, z-STED imaging and spectroscopy to investigate nanoscale membrane structure and dynamics, Biophysical Journal, (2020)
55. Sezgin E, Carugo D, Levental I, Stride E, Eggeling C, Creating supported plasma membrane bilayers using acoustic pressure, Membranes, 10(2), 30, (2020)
54. Lorent JH, Levental K, Ganesan L, Rivera-Longsworth G, Sezgin E, Doktorova M, Lyman E, Levental I, Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape, Nature Chemical Biology , (2020)
53. Beckers D, Urbancic D, Sezgin E, Impact of nanoscale hindrances on the relationship between lipid packing and diffusion in model membranes, Journal of Physical Chemistry B (2020)
52. Ballweg S, Sezgin E, Wunnicke D, Hänelt I, and Ernst R, Regulation of lipid saturation without sensing membrane fluidity Nature Communications, 756 (2020).
See press release here
51. Schneider F, Hernandez-Varas P, Lagerholm CB, Shrestha D, Sezgin E, Roberti MJ, Ossato G, Hecht F, Eggeling C, Urbancic I, High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy. Journal of Physics D, 53, 164003 (2020)
2019
50. Azbazdar Y, Ozalp O, Sezgin E, Veerapathiran S, Duncan A, Sansom M, Eggeling C, Wohland T, Karaca E, Ozhan G. More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Frontiers in Cell and Dev Biology, (2019)
49. Steinkuhler J, Sezgin E, Urbancic I, Eggeling C, Dimova R. Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density. Communications Biology, (2019)
48. Pinkwart K, Schneider F, Lukoseviciute M, Sauka-Spengler T, Lyman E, Eggeling C, Sezgin E. Nanoscale dynamics of cholesterol in the cell membrane. Journal of Biological Chemistry, (2019)
47. Axmann M, Sezgin E, Karner A, Novacek J, Brodesser MD, Röhrl C, Preiner J, Stangl H, Plochberger B. Receptor-Independent Transfer of Low Density Lipoprotein Cargo to Biomembranes. Nano Letters, 19(4), 2562-2567, (2019)
46. Sezgin E, Schneider F, Galiani S, Urbančič I, Waithe D, Lagerholm BC, Eggeling C. Measuring nanoscale diffusion dynamics in cellular membranes with super-resolution STED-FCS. Nature Protocols, 14(4), 1054-1083, (2019)
2018
45. Felce JH*, Sezgin E*, Wane M, Brouwer H, Dustin ML, Eggeling C, Davis SJ. CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity. Science Signalling, 11(561), (2018)
44. Jenkins E, Santos AM, O'Brien-Ball C, Felce JH, Wilcock MJ, Hatherley D, Dustin ML, Davis SJ, Eggeling C, Sezgin E. Reconstitution of immune cell interactions in free-standing membranes. Journal of Cell Science, 132(4), (2018)
43. Mobarak E, Javanainen M, Kulig W, Honigmann A, Sezgin E, Aho N, Eggeling C, Rog T, Vattulainen I. How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative. BBA Biomembranes, 1860(11), 2436-2445, (2018)
42. Schneider F, Waithe D, Lagerholm BC, Shrestha D, Sezgin E, Eggeling C, Fritzsche M. Statistical Analysis of Scanning Fluorescence Correlation Spectroscopy Data Differentiates Free from Hindered Diffusion. ACS Nano, 12(8), 8540-8546, (2018)
41. Schneider F, Waithe D, Galiani S, Bernardino de la Serna J, Sezgin E*, Eggeling C*. Nanoscale Spatiotemporal Diffusion Modes Measured by Simultaneous Confocal and Stimulated Emission Depletion Nanoscopy Imaging. Nano Letters, (2018) (*co-correspondence)
40. Reina F, Galiani S, Shrestha D, Sezgin E, de Wit G, Cole D, Christoffer Lagerholm B, Kukura P, Eggeling C. Complementary studies of lipid membrane dynamics using iSCAT and super-resolved fluorescence correlation spectroscopy. Journal of Physics D, (2018)
39. Xiong Y, Jentzsch AV, Osterrieth JWM, Sezgin E, Sazanovich IV, Reglinski K, Galiani S, Parker AW, Eggeling C, Anderson HL. Spironaphthoxazine switchable dyes for biological imaging Chemical Science, (2018)
38. Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J. Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. European Journal of Immunology, (2018)
2017
37. Plochberger B, Röhrl C, Preiner J, Rankl C, Brameshuber M, Madl J, Bittman R, Ros R, Sezgin E, Eggeling C, Hinterdorfer P, Stangl H, Schütz GJ. HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study. Scientific Reports, 7(1), 15886, (2017)
36. Sezgin E, Schneider F, Zilles V, Urbančič I, Garcia E, Waithe D, Klymchenko AS, Eggeling C. Polarity-Sensitive Probes for Superresolution Stimulated Emission Depletion Microscopy. Biophysical Journal, (2017)
35. Diepold A, Sezgin E, Huseyin M, Mortimer T, Eggeling C, Armitage JP. A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome. Nature Communications, 8, 15940, (2017)
34. Sezgin E*, Azbazdar Y, Ng XW, Teh C, Simons K, Weidinger G, Wohland T, Eggeling C, Ozhan G*. Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments. FEBS Journal, (2017) (*co-correspondence)
33. Sezgin E. Super-resolution optical microscopy for studying membrane structure and dynamics. Journal of Physics Condensed Matter, (2017)
32. Aron M, Browning R, Carugo D, Sezgin E, Bernardino de la Serna J, Eggeling C, Stride E. Spectral imaging toolbox: segmentation, hyperstack reconstruction, and batch processing of spectral images for the determination of cell and model membrane lipid order. BMC Bioinformatics, 18 (1), 254 (2017)
31. Rissanen S, Grzybek M, Orlowski A, Rog T, Cramariuc O, Levental I, Eggeling C, Sezgin E*, Vattulainen I*. Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin Frontiers in Physiology, (2017) (*co-correspondence)
30. Schneider F, Waithe D, Clausen MP, Galiani S, Koller T, Ozhan G, Eggeling C*, Sezgin E*. Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS. Molecular Biology of the Cell, (2017) (*co-correspondence)
29. Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane organization: composition, regulation and roles of lipid rafts Nature Reviews Molecular Cell Biology, (2017)
28. Pereno V, Carugo D, Bau L, Sezgin E, de la Serna JB, Eggeling E, Stride E. Electroformation of giant unilamellar vesicles on stainless steel electrodes, ACS Omega, 2(3), 994–1002 (2017)
27. Koller T, Blok S, Santos AM, Oszmiana A, Davis DM, Sezgin E*, Eggeling C. Rituximab capping triggers intracellular reorganization of B cells. Matters, (2017) (*correspondence)
26. Amaro M, Reina F, Hof M, Eggeling C, Sezgin E*. Laurdan and Di-4-ANEPPDHQ probe different properties of the membrane. Journal of Physics D: Applied Physics, 50(13), 134004-134013, (2017)
25. Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras G, Betzig B, Eggeling C. Self-organizing actin patterns shape membrane architecture but not cell mechanics. Nature Communications, 8, 14347 (2017)
24. Carugo D, Aron M, Sezgin E, Bernardino de la Serna J, Kuimova MK, Eggeling C, Stride E. Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles. Biomaterials, 113, 105-117 (2016)
2016
23. Xiong Y, Rivera-Fuentes P, Sezgin E, Vargas Jentzsch A, Eggeling C, Anderson HL. Photoswitchable Spiropyran Dyads for Biological Imaging. Organic Letters, 18(15), 3666-3669 (2016)
22. Steshenko O, Andrade DM, Honigmann A, Mueller V, Schneider F, Sezgin E, Hell SW, Simons M, Eggeling C. Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy. Biophysical Journal, 110(11), 2441-2450 (2016)
21. Hölttä-Vuori M, Sezgin E, Eggeling C, Ikonen E. Use of BODIPY-cholesterol (TF-Chol) for visualizing lysosomal cholesterol accumulation. Traffic, (2016)
20. Sezgin E*, Can FB, Schneider F, Clausen MP, Galiani S, Stanly TA, Waithe D, Colaco A, Honigmann A, Wuestner D, Platt F, Eggeling C*. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters. Journal of Lipid Research, (2016). (*co-correspondence)
2015
19. Waithe D, Clausen MP, Sezgin E, Eggeling C. FoCuS-point: Software for STED Fluorescence Correlation and Time-Gated Single Photon Counting. Bioinformatics, (2015).
18. Vicidomini G, Ta H, Honigmann A, Mueller V, Clausen MP, Waithe D, Galiani S, Sezgin E, Diaspro A, Hell SW, Eggeling C. STED-FLCS: An Advanced Tool to Reveal Spatiotemporal Heterogeneity of Molecular Membrane Dynamics. Nano Letters, 15(9), 5912-5918, (2015).
17. Clausen MP, Sezgin E, de la Serna JB, Waithe D, Christoffer Lagerholm B, Eggeling C. A straightforward approach for gated STED-FCS to investigate lipid membrane dynamics. Methods, 88, 67-75, (2015).
16. Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun U, Solimena M, Simons K, Levental I*, Schwille P*. Adaptive lipid packing and bioactivity in the membrane domains. PLOS ONE, 10(4); e0123930 (2015).
15. Sezgin E, Davis SJ, Eggeling C. Membrane nanoclusters—tails of the unexpected. Cell, 161, 433-434 (2015).
14. Sezgin E*, Waithe D, Bernardino de la Serna J, Eggeling C*. Spectral Imaging to measure heterogeneity in membrane lipid packing. Chemphyschem, 16(7), 1387-1394. (2015). (*co-correspondence)
13. Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW. Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains. BBA Molecular Cell Research, 1853 (4), 802-809, (2015).
2014
12. Honigmann A, Mueller V, Ta H, Schoenle A, Sezgin E, Hell SW, Eggeling C. (2014) Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells. Nature Communications, 5, 5412, (2014).
11. Sezgin E*, Sadowski T, Simons K*. Measuring Lipid Packing of Model and Cellular Membranes with Environment Sensitive Probes. Langmuir, 30, 8160-8166, (2014). (*co-correspondence)
2013
10. Zhou Y, Maxwell KN, Sezgin E, Lu M, Liang H, Hancock JF, Dial EJ, Lichtenberger LM, Levental I. Bile acids modulate signaling by functional perturbation of plasma membrane domains. Journal of Biological Chemistry, 288, 35660-35670, (2013).
9. Sezgin E, Chwastek G, Aydogan G, Levental I, Simons K, Schwille P. Photoconversion of Bodipy-Labeled Lipid Analogues. Chembiochem, 14, 695-698, (2013).
8. Ozhan G, Sezgin E, Wehner D, Pfister A, Kuhl S, Kagermeier-Schenk B, Kuhl M, Schwille P, Weidinger G. Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Developmental Cell, 26, 331-345, (2013).
2012
7. Sezgin E, Kaiser H-J, Baumgart T, Schwille P, Simons K, Levental I. Elucidating membrane structure and protein behavior using giant plasma membrane vesicles. Nature Protocols, 7, 1042-1051, (2012).
6. Sezgin E, Levental I, Grzybek M, Schwarzmann G, Mueller V, Honigmann A, Belov VN, Eggeling C, Coskun U, Simons K, Schwille P. Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. BBA-Biomembranes, 1818, 1777-1784, (2012).
5. Dubavik A*, Sezgin E*, Lesnyak V, Gaponik N, Schwille P, Eychmueller A. Penetration of Amphiphilic Quantum Dots through Model and Cellular Plasma Membranes. ACS Nano, 6, 2150-2156, (2012). (*co-first author)
4. Saenz JP, Sezgin E, Schwille P, Simons K. Functional convergence of hopanoids and sterols in membrane ordering. PNAS, 109, 14236-14240, (2012).
3. Sezgin E and Schwille P. Model membrane platforms to study protein-membrane interactions. Molecular Membrane Biology, 29, 144-154,(2012).
2011
2. Sezgin E and Schwille P. Fluorescence Techniques to Study Lipid Dynamics. Cold Spring Harbor Perspectives in Biology, 3, (2011).
2009
1. Karatas OF, Sezgin E, Aydin O, Culha M. Interaction of gold nanoparticles with mitochondria. Colloids and Surfaces B-Biointerfaces, 71, 315-318, (2009).
